Safety evaluation and risk assessment

Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarettes substitutes: A systematic review


A new study was published today in the journal Therapeutic Advances in Drug Safety. The paper, co-authored by Dr Konstantinos Farsalinos from the Onassis Cardiac Surgery Center in Greece and Prof Riccardo Polosa from the University of Catania in Italy, is a systematic review of all studies on the safety and risk profile of e-cigarettes. A total of 114 studies are referenced in this paper, with 97 directly related to e-cigarettes or their ingredients. The review covers all aspects, from chemical to clinical studies, including studies evaluating the potential effects of selected ingredients of e-cigarettes such as propylene glycol and glycerol. It includes discussion about the effects of nicotine and findings from studies evaluating passive exposure to e-cigarette aerosol.

Evaluation of the cytotoxic

Evaluation of the cytotoxic potential of e-cigarette vapor on cultured cardiac cells: a new study


A new study on electronic cigarettes was published today in International Journal of Environmental Research and Public Health. Researchers from Onassis Cardiac Surgery Center in Greece and Abich Toxicological Laboratory in Italy, lead by principle investigator Dr Konstantinos Farsalinos evaluated the cytotoxic potential of 20 different e-cigarette liquids (in vapor form) on cultured cardiac cells. Importantly, vapor was produced by using a commercially available e-cigarette device. Moreover, the effects of vapor produced using a new-generation high voltage device was examined for the first time. For comparison, the effects of tobacco cigarette smoke were also evaluated. The results of the study showed that e-cigarette vapor was by far less cytotoxic than tobacco cigarette smoke, with most of the samples showing absolutely no adverse effects on the cells.



Regulation on e-cigarettes

 Negotiations within EU concerning regulation of e-cigarettes are still underway but close to the end. Unfortunately, current proposals (displayed in detail by Clive Bates) are so much different compared to those voted by the EU Parliament that one wonders why was the will of the MEPs completely ignored and bypassed. In any case, the new proposals are extremely damaging for public health. They will definitely drive vapers back to smoking and will reduce any chance of smokers switching to e-cigarettes as a significantly less harmful alternative. Regulators should realize that the intention to ensure quality products in the market is not fulfilled by banning most of the products that current consumers use. The same goal can be achieved by introducing some very simple and realistic rules to the article 170 voted by the MEPs in October.

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